The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is sputtering to the finish line. They are significant underdogs to the San Francisco 49ers despite being at home on Monday Night Football in Week 16.

Kyle Shanahan, Christian McCaffrey and more speak to reporters before San Francisco’s practice on Thursday in Santa Clara.Kyle Shanahan, 49ers preview San Francisco's crucial Week 16 matchup vs. Colts

A lot of the 49ers' biggest contributors weren't on the team last year. Heck, some of them weren't even on the team in Week 1.

The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San Francisco gets in.

www.si.com/nfl/49ers/onsi These San Francisco 49ers should make the 2025 Pro Bowl Brian Walshe is set to be sentenced on Thursday after a Massachusetts jury found him guilty of killing and dismembering his wife, the mother of their three children.

For NFL WAG Sydney Warner, football season is about as busy as it can get this year. With her husband, San Francisco 49ers linebacker Fred Warner, Sydney already has one kid under two — her son Beau — and now, the couple has another on the way!

The San Francisco 49ers (10-4) enter Week 16 as 5.5-point favorites against the Indianapolis Colts, aiming to extend their winning streak to five games as they push toward a return to the NFL postseason. With a victory on Monday night at Lucas Oil Stadium, the 49ers would...

Highlighting the San Francisco 49ers interns, their career paths, roles within the organization, and advice for aspiring professionals.

The Colts are currently riding a four-game losing streak, which is the fourth-longest active streak in the league. If the Colts want to end that, they'll have to dominate the 49ers in these three areas on Monday night.