Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

The membrane that encases a biological cell is not simply a barrier; it is chock full of proteins involved in all sorts of critical biological functions. To really understand what membrane proteins ...

Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these ...

Inside your body on the surface of cell membranes, a metaphorical communication and traffic network is underway as hormones - or chemical messengers - bind to cell membrane receptors to fine tune how ...

The upper size limit on cell-penetrating drug molecules may be much higher than medicinal chemists had thought. A research team reports that molecules believed to be much too large to diffuse across ...

Membrane proteins are some of the most valuable targets in drug discovery, accounting for over half of all therapeutic targets. However, their inherent structural diversity and the complexity of their ...

(Nanowerk News) Just as countries import a vast array of consumer goods across national borders, so living cells are engaged in a lively import-export business. Their ports of entry are sophisticated ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

Edward Lyman, associate professor in the departments of physics and astronomy, as well as chemistry and biochemistry, was recently published in the journal Nature Chemical Biology. The article, “When ...