The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster ...

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is ...

Niners bolster QB depth with Adrian Martinez's return and scout offensive line talent, preparing for playoff challenges and ...

The 49ers (10-4) have a better shot at the NFC’s No. 1 seed and a potential Super Bowl home game thanks to the Seattle ...

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 ...

The 49ers running game has been up and down, but they could have an advantage against a very solid Colts run defense ...

This article was originally published on www.si.com/nfl/49ers/onsi as One 49ers player is almost guaranteed to get a $500k ...

The Niners’ longtime NFC West foe pulled off a miraculous comeback Thursday against the Rams, erasing a 16-point deficit, ...

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, ...

The San Francisco 49ers won't play their Week 16 game until Monday night, but they've already benefitted from a massive game ...

San Francisco 49ers wide receiver Ricky Pearsall has missed the team's first practice of the week due to knee and ankle ...