It can be tempting for the San Francisco 49ers to overlook the Indianapolis Colts this week. After starting the season 7-1, ...

With help from their Football Power Index tool, ESPN simulated the remainder of the 2025 season for the Indianapolis Colts.

It's now or never for the Indianapolis Colts when they defend home turf against the San Francisco 49ers on Monday night.

The 49ers running game has been up and down, but they could have an advantage against a very solid Colts run defense ...

Colts defensive tackle DeForest Buckner told reporters Friday he's still uncertain whether he'll play in Monday Night ...

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 ...

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, ...

Indianapolis Colts' wide receiver Alec Pierce appeared on the team's first Week 16 injury report. Pierce was listed as a ...

The Indianapolis Colts and San Francisco 49ers understand the stakes Monday night. Both teams find themselves in the throes ...

San Francisco 49ers wide receiver Ricky Pearsall has missed the team's first practice of the week due to knee and ankle ...

Colts quarterback Philip Rivers should face less pressure his second week back in the NFL, as his team plays the 49ers on ...

The Indianapolis Colts may look to acquire a former Pro Bowler to help solve their precarious quarterback situation in 2026.