The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster ...

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is ...

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 ...

Veteran Philip Rivers' improbable return from retirement ignites a thrilling road game as the 49ers face the surging Colts.

The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are ...

It looks like the Indianapolis Colts are rolling with Philip Rivers again for their Monday night matchup against the San ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers ...

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16 ...

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, ...

The Indianapolis Colts and San Francisco 49ers face off in "Monday Night Football" this week. Check out how to watch on ESPN now.

INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in ...